Mesothelioma Prognosis - What Are Your Chances?

About 2000 to 3000 new cases of mesothelioma are diagnosed each year in the United States. Once a patient receives a diagnosis of this cancer, his or her physician will most likely discuss the prognosis or probable course and outcome of the disease with the patient.

Factors That Determine Prognosis

Most times a diagnosis of mesothelioma is made when the cancer has reached an advanced stage as it usually takes a very long amount of time after the contact with asbestos before most victims start displaying the symptoms associated with the disease.

In addition to this fact, even when the symptoms of this cancer do eventually surface, they often resemble the symptoms of more general diseases like pneumonia, influenza and some other lung diseases. This fact coupled with the long delay in appearance of symptoms makes the accurate diagnosis of mesothelioma a very difficult one.

Thus as result of these factors, prognosis for majority of the patients is poor, but many doctors recommend treatment options like surgery, chemotherapy, and radiotherapy to help combat the disease.

Factors that affect prognosis include:

A} The stage of the cancer:

Medically the progression of the cancer is classified in form of stages. The stages range from stage one to stage four. The higher the stage the, the more advanced the cancer. Unfortunately, once the cancer has reached stages three to stage four, treatment options become limited and less effective. In stage four of the cancer, the cancer has spread to other parts of the body and the tumor has often deeply eaten into various key organs and tissues in the body. Stage 4 is not suitable for surgery. Generally the higher the stage of the cancer the worse the prognosis.

B} Histological type of cancer:

Histology refers to the basic cell structure and type of the cancer. Histologically, there are four types of mesothelioma:a}Epithelial,b}Sarcomatoid c}Biphasic{mixed} d}Desmoplastic{variant of sarcomatoid}
Epithelial mesothelioma has a better prognosis than the other types and the sarcomatoid form has the worst prognosis.

C} Age and general condition of victim

Malignant mesothelioma is often diagnosed in people above the age of 55 years old, although there may be exceptions. So some of the victims would have developed chronic diseases associated with old age like diabetes and hypertension and this worsens their prognosis.

D} The size of the tumor

E} The location of the tumor and whether the tumor is operable{whether it can be removed surgically}

F} The extent of other symptoms, including fluid in the lungs or abdomen.

G} Whether or not the patient is a smoker.

When discussing the survival rate of any cancer, references are often made to the "five year survival rate". The five year survival rate refers to the percentage of patients who live at least five years after receiving their diagnosis. According to the American Cancer Society, the five year survival relative survival rate for mesothelioma is approximately 10%.The number has improved over the last five years up from the 9% reported at the end of 2002.
In general, the average length of survival reported throughout the last five years has been 10-11 months after diagnosis.
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Mesothelioma Treatment With TomoTherapy Radiation Presented at ESTRO

In a presentation currently taking place in Barcelona, Spain, researchers are showing the results of 82 different studies evaluating the benefits of TomoTherapy radiation.

TomoTherapy Incorporated, a maker of advanced therapy solutions for cancer care, has examined the use of the TomoTherapy treatment system on a number of complex and rare tumors that exist throughout the body, including mesothelioma.

Mesothelioma is a rare form of cancer almost exclusively caused by asbestos exposure. Treating this condition can be very difficult because no cure is currently available. In most cases, patients elect to receive palliative treatment in an effort to extend their mesothelioma life expectancy and relieve discomfort.

The European Society for Therapeutic Radiology and Oncology (ESTRO) 29 conference began on September 12 and will continue through September 16. In addition to mesothelioma, the TomoTherapy system was tested on head, neck, prostate, breast and lung tumors as well.

In one of the most encouraging studies, researchers from San Raffaele Scientific Institute in Milan, Italy tested TomoTherapy against other radiation therapy solutions to determine if TomoTherapy could improve target coverage without damaging nearby organs. The researchers said, “For all simulations, RapidArc(R) met less of the optimization criteria, while TomoTherapy was able to produce the most homogeneous dose and have the capability to conform dose distributions better than RapidArc(R).”

The use of TomoTherapy in treating more complex cases was demonstrated in a mesothelioma study that evaluated two groups of patients, with one group receiving a simultaneous integrated boost (SIB). The SIB group experienced significant success as their one-year survival rate increased to 72 percent. The other group had a one-year survival rate of 43 percent.

In addition, patients that received a SIB did not have a relapse in mesothelioma development for an average of 16 months. The non-SIB group experienced a relapse in an average of six months.

Improving the survival rate of mesothelioma patients through new methods of treatment is promising in a field that has been searching for a cure for decades. While treatments such as TomoTherapy radiation may not permanently remove the cancer, this kind of research does bring hope to patients living with a fatal condition.
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Mesothelioma Survival

Mesothelioma Survival Rate May Improve with Multimodality Therapy
While clinical trials and research studies have made great advancements in understanding mesothelioma cancer, a cure has yet to be discovered. Presently, data shows the best hope for extending a mesothelioma patient’s life span is to undergo multimodality therapy, where more than one form of aggressive therapy is combined to enhance treatment effect.

Malignant mesothelioma is a rare cancer caused almost exclusively by asbestos exposure. The mesothelioma life expectancy currently ranges between four and 18 months. Every year in the United States approximately 2,000 to 3,000 new cases of mesothelioma are reported.

Due to the long latency period associated with the cancer, many patients will not experience related symptoms until 20 to 50 years after exposure. By this time, the disease has already progressed to later stages of development. Unfortunately, most symptoms of mesothelioma are also found with less serious conditions and can lead to a wrong diagnosis or a delay in accurate diagnosis. The later the cancer is diagnosed, the more difficult it is to treat.

Mesothelioma rarely responds positively to just one mode of treatment. Doctors and researchers have learned that combating the cancer successfully calls for more than one mode of treatment. Commonly called multimodality therapy, this approach unites treatments such as chemotherapy, surgery, radiotherapy or some unique form of treatment like immunotherapy to improve mesothelioma life expectancy.

In most cases, opting for multimodality therapy adds months to the patient’s life expectancy, which ranges depending up each individual case. However, a number of mesothelioma survivors found salvation in choosing to undergo multimodality therapy, which has been known to help some patients survive the cancer for five years and beyond. With increasing reports of mesothelioma survivors and growing research breakthroughs, much hope is available to recently diagnosed mesothelioma patients looking to improve their life expectancy.

Additional information on mesothelioma may be found through the Mesothelioma Center.
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The Dangerous Disease Mesothelioma

The name does ring a bell, it is a form of cancer which is rare in nature. The lung surface gets affected and this condition occurs when an individual is exposed to asbestos for long stretches of time. It is also referred to as asbestos cancer. However, this does not mean that no one else would attract this health condition. Constant exposure to asbestos is the primary cause for this disease. When the fibers get trapped in the body, the body produces a counter acid to fight these fibers. In the process, the tissues surrounding the lungs get damaged which results in difficulty in breathing and wheezing. The lungs get scarred in this process.

People who renovate their homes or buildings and are exposed to asbestos have a greater risk of attracting this health condition. The disease does not spread through physical contact however. It was researched and established that individuals who worked at naval shipyards were the first individuals to attract this condition.

It has been found that individuals who have in no way been connected to or related to asbestos also have suffered the disease. The main reason for the cause of this severe condition is irradiation and inhaling the fibrous silicates. Basically, the mesothelial cells are the ones which encircle our organs and the cancer which takes place within the cells is referred to as mesothelioma. The three types of mesothelial cells are biphasic, sacromatoid and epitheliod. They normally occur in combinations of the above cells.

The epitheliod cells are the commonest of cancer cells. This cell is cubical in shape and in groups they appear tubular in nature. The biphasic mesothelial cells are uncommon and they account for thirty percent of the mesothelioma cells. If the other two cells are present in combination, then biphasic cells occur. The most unusual of them being the sarcomatoid. It is an oval irregular shaped cell and the nucleus is invisible.

Many a times, mesothelioma is attracted from non malignant and benign cells. This type of cell can be treated by surgery. The symptoms associated with this disorder are pain in chest, difficulty in breathing and constant coughing. The fluid gets accumulated in the pleural area of lungs making it difficult for an individual to breathe. Other associated symptoms include tiredness, nausea, wheezing, anaemia, blood in sputum. Extreme cases result in lung collapse and in some severe cases, the cancer spreads rapidly to other body parts. Normally, the symptoms appear after 20-25 years of being exposed to asbestos. There are varied methods to treat this condition, if detected at an early stage which is practically not possible. Some of the common methods used to treat this condition are chemotherapy, radiation and surgery. Doctors and researchers are also trying out traditional and conservative methods of treating this health condition. If this condition is left untreated, it could lead to heart related problems.

If an individual has been diagnosed with this health condition, one needs to resort to the next course of medical condition immediately without wasting further time.
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What is This-Malignant Sarcomatoid Mesothelioma?

In histological terms, there are four different types of mesothelioma: sarcomatoid, epithelial, biphasic, and desmoplastic (a variant of sarcomatoid).In medical terms, the term histopathology refers to the microscopic examination of cellular tissue to gain insight into the manifestations of various diseases.

Malignant sarcomatoid mesothelioma is the least common of the four cellular types. It accounts for approximately 7 to 20 percent of cases. When viewed under a microscope,the malignant cells appear as elongated spindle-shaped cells that are irregularly shaped and often overlap one another.

Desmoplastic mesothelioma is considered a variant of sarcomatoid mesothelioma. This form is likely the most difficult of all mesotheliomas to diagnose. When desmoplastic mesothelioma invades or metastasizes, the cells can appear very bland and can be misdiagnosed as benign fibrous tissue. Medical experts say this form should not be diagnosed with a needle core biopsy. It's important to know that malignant sarcomatoid mesothelioma is sometimes difficult to diagnose on the basis of histological methods. For example, cells of another type of cancer called pulmonary sarcomatoid carcinoma are very similar in appearance (as well as other characteristics) to malignant sarcomatoid mesothelioma.

For this reason, if you are diagnosed with cancer and you know that you have been exposed to asbestos at some time in the past, obtaining a second diagnostic opinion may be important. Different types of cancer vary widely in terms of prognosis and treatment options, and if misdiagnosed, patients may not receive the most appropriate treatment for their cancer.

Treatment and Prognosis

Each of the four cellular forms of mesothelioma is generally treated in the same way. Treatment is not based on the specific type of cells involved, but instead on the location of tumors and the stage of the cancer. Each type of cancer responds to treatment very differently. In general, patients with malignant sarcomatoid mesothelioma have a poorer prognosis than patients with the epithelioid type , as sarcomatoid cancers are more aggressive and more resistant to treatment. Unfortunately, the general prognosis for all the different types is usually poor, and the difference in prognosis between sarcomatoid, epithelioid, biphasic and desmoplastic cancers may amount to as little as a few months.

Biopsy and Histopathology

Patients undergoing medical evaluation to ascertain a diagnosis of mesothelioma will also have to undergo a variety of medical tests to determine the location and nature of the cancer.
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Mesothelioma Cancer Cell Types Epithelioid Sarcomatoid Biphasic

Mesothelioma is one of the deadliest cancers for a number of reasons. It has a prolonged latency period during which it destroys the mucous-producing membrane that lines the outer surface of a number of organs. This membrane allows the organs to move, which in turn allows them to function. Over a period of decades mesothelioma destroys healthy cells by assaulting them with three main avenues of attack: epithelioid, sarcomatoid, biphasic cells.

Epithelioid mesothelioma cells are the most common and relatively easiest to treat of all types of mesothelioma. This type of cell appears to be a papillary or tubular growth that usually affects the outer membranes and linings of the internal organs and other bodily surfaces. Somewhere between 50 and 70% of all mesothelioma cases belong to this category, and although this cancer is usually extremely difficult to treat, epithelioid mesothelioma is the most likely to respond to treatment.

The second type of mesothelioma is sarcomatoid mesothelioma. This type is the most serious form of the disease, as it is the least likely to respond to treatment. These spindle-shaped pattern of cells that appear to overlap each other are also fortunately the rarest type of the cancer, with approximately 10-20% of all mesothelioma cases falling into this type. Sarcomatoid mesothelioma is so dangerous because it attacks and arises from the support tissues of the body, such as bone, cartilage, fat, and muscle, and cancers in these areas are notoriously difficult and painful to treat. Patients with this form of cancer rarely live longer than six months after diagnosis.

The final condition, biphasic mesothelioma, is not an independent type of mesothelioma, but a combination of sarcomatoid and epithelioid. It is also a mixed bag of conditions in that it can take the good and bad aspects of the other two types, and almost 20-35% of all mesothelioma cases fall into either mixed or biphasic areas.

Without a doubt, mesothelioma is one of the most devastating types of cancer. Most people rarely live beyond a year after their initial diagnosis, and few victims reach five years. Mesothelioma is almost always caused by asbestos exposure, and millions of people have had contact with this deadly substance.
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Mesothelioma Litigation Fact

Mesothelioma litigation is an option for mesothelioma patients. Litigation however is not an easy path to consider. Before you choose to sue, there are a couple of crucial facts that you should be aware of.

You have the right to sue.

In some cases, your condition may be caused by the negligence of others. Mesothelioma is a type of cancer that results from exposure to asbestos fibers. Like any average individual, you probably wouldn't consider exposing yourself to asbestos of your own free will. You may have been exposed to asbestos due to your work or due to a family member who works with asbestos.

So why should you sue if you find out you have mesothelioma? Companies that hire individuals to work on asbestos would typically know that there are certain dangers involved in handling the mineral. Company safety rules should therefore be strictly implemented to prevent asbestos exposure. If you develop mesothelioma, it may be due to a company's inability to protect and warn people against the dangers of asbestos.

Different states have different laws regarding mesothelioma cases.

Mesothelioma litigation procedures aren't always the same. Different states have different rules and laws covering mesothelioma cases. One thing is common though, various localities have their own set specific time frames for litigation procedures. It is therefore very important that you seek legal assistance as soon as you have been diagnosed with mesothelioma. If you act too late, you may not be able to get the monetary compensation that is rightfully yours.

Not every lawyer can handle a mesothelioma case.

Some lawyers do not handle mesothelioma litigations. Not every lawyer however is ready or equipped to do so. Every lawyer has his/her own line of specialty. There are therefore some lawyers who know better how to handle a mesothelioma case. A mesothelioma lawyer would know better the legal technicalities, laws and details involved in a mesothelioma case. Other than these, he would also have sufficient disease knowledge to help clients trace exposure details and determine the extent of physical, emotional and financial damage.

Time is of the essence in a mesothelioma case. This does not mean though that you should be haphazard in your choice of a lawyer. Make sure that the expert that you pick has had some background and success in mesothelioma cases. A good lawyer can make the difference between prompt financial or emotional relief and absolute loss.

Litigation can be expensive.

Like any form of lawsuit, mesothelioma cases can also be costly. Many legal entities however are aware that many clients are not able to pay outright. The collection of fees is therefore postponed until damages are awarded. Be warned though that attorney's fees for mesothelioma cases can be quite steep. Lawyers can collect up to 40% of the total amount awarded. For many patients though this is already considered a fair deal. After all, mesothelioma cases are not easy to handle and win.

Mesothelioma litigation may not be easy. The compensation however, that you can hope to get after the procedure can be a great help to you and your family.
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